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2020年4月7日 星期二

英國在測試9家廠商的效度:faulty antibody kits。Potential coronavirus vaccine 'generates enough antibodies to fight off virus'。中國找出有效抗體;Columbia Starts Screening COVID-19 Survivors for Antibodies That May Save Others抗體檢測Testing coronavirus survivors’ blood could help reopen America。Researchers Rush to:produce blood test for coronavirus immunity. New blood tests for antibodies could show true scale of coronavirus pandemic. 據說美國 9 月就能把疫苗用在人身上、台灣疫苗國家隊的研發潛力與限制Home Test Kits: Test Coronavirus Vaccine in People. 美國新冠疫苗開始人體測試,時間早於預期。As pressure for coronavirus vaccine mounts, scientists debate risks of accelerated testing


Britain’s effort to speed up coronavirus testing hit by faulty antibody kits

Oxford University researchers found that many of the rapid-test kits can’t accurately show whether someone was exposed to the virus
The government had ordered more than 4 million of these tests, which can be as simple as finger-prick devices


美國食品藥品監督管理局(FDA)週四批准了在該國使用的首個新冠病毒抗體測試。此前,抗體測試已在中國、新加坡和其他一些國家使用。英國英國公共衛生部已購入數百萬個抗體測試,以用於對該國民眾進行檢測。此外,新澤西州一家生物技術公司週四稱,一種源自人類胎盤的實驗性幹細胞療法將開始在冠狀病毒患者中進行早期試驗。


The US Food and Drug Administration has issued its first emergency use authorization for a coronavirus test that looks for antibodies in the blood. Unlike most coronavirus tests, which generally require a swab and look for signs of the virus itself, antibody tests look instead for our body's response to a virus.

CNN.COM


FDA authorizes first coronavirus antibody test

英國政府飽受批評。

Britain has checked a total of 135,000 people, compared with 500,000 a week in Germany. Failure to test NHS workers has greatly exacerbated the staff shortage in hospitals


抗體測試法或許能幫點忙:英國在測試9家廠商的效度


找出有效抗體的方式還有另一種方式,即某些可能的"疫苗"作得到:


INDEPENDENT.CO.UK
Potential coronavirus vaccine 'generates enough antibodies to fight off virus'

A team of Chinese scientists has isolated several antibodies that it says are "extremely effective" at blocking the ability of the new coronavirus to enter cells, which eventually could be helpful in treating or preventing COVID-19.

Columbia Public Health

Diana Berrent survived Covid-19. Now she's heading to Columbia University Irving Medical Center to be donor number one in its plasma study.




CUIMC.COLUMBIA.EDU

Columbia Starts Screening COVID-19 Survivors for Antibodies That May Save Others For the first time in New York state, a COVID-19 survivor has been screened for antibodies that could be used to treat others with the disease.



Serology tests that measure coronavirus antibodies could restart society, but this will require accurate, widespread testing and more information about immunity.


WASHINGTONPOST.COM

Testing coronavirus survivors’ blood could help reopen America


U.S. firms and labs rush to produce blood test for coronavirus immunity


In Pamela Bjorkman's lab, the team is now investigating the coronavirus spikes and the antibodies created by the immune system to recognize them.


And in the lab of Andre Hoelz, an investigation is underway into how the virus shuts down the machinery of its host cell using a protein common to many kinds of coronaviruses.

CALTECH.EDU

Caltech Scientists Turn Research Toward Fighting Coronavirus Pandemic


DW 中文 - 德國之聲

《明鏡週刊》報導稱,德國多家學術機構正在醞釀一項大規模的抗體檢測。一方面,這項工作有助於瞭解痊癒者到底是否對新冠病毒具備免疫力;另一方面,價格相對低廉的抗體檢測也有助於流行病學專家更為準確地掌握疫情的全局
DW.COM

德國學者想知道:親愛的你有抗體嗎?


《明镜周刊》报道称,德国多家学术机构正在酝酿一项大规模的抗体检

 tests—which look for antibodies, not viruses—could be a game-changer in our understanding of the #coronavirus pandemic. Scientists are racing to develop them.

SCIENCEMAG.ORG
New blood tests for antibodies could show true scale of coronavirus pandemic
Large-scale testing of populations should reveal those who clear
鍾南山表示,很快地生產出有效疫苗是當前重要任務。美國據說 9 月就能把疫苗用在人身上,中國也在和時間賽跑,預計前後不會差太多。廣東目前在做核酸疫苗,在做動物實驗,也有腺病毒作為載體的疫苗,希望在 2、3 個月的時間能有大的進展。我們對所有國家都是支持的態度,現在中國大量出口核酸試劑。

【掌握世界專利與重要王牌,台灣疫苗國家隊的研發潛力與限制】


隨著COVID-19疫情在全球延燒,全世界升級防疫之餘,也全面投入研發預防傳染病的關鍵武器──疫苗。


美國16日首先傳出好消息,「mRNA疫苗」已展開人體實驗,而台灣也有捷報,#中研院 具全球專利的「奈米疫苗」,在動物前測出現明顯效果。#國衛院 2月初同時投入「胜肽」、「DNA」、「重組病毒」、「次單位」4種疫苗研發,其中2種已進入動物測試階段。


不同類型的疫苗有各自的優勢與潛藏問題,台灣為何選擇上述5種疫苗研發?全球疫苗競速下,勝敗的關鍵是什麼?如何搶快又顧及安全性?


《報導者》採訪台灣疫苗研發團隊,不只告訴你疫苗研發的方式與特性,剖析台灣疫苗競爭的潛力!


Bloomberg

Using technology from home pregnancy and malaria tests, this hand-held kit could be ready for sale by June for less than $1.




美國新冠疫苗開始人體測試,時間早於預期。美國國家衛生研究院週一表示,該研究院資助的一種新型冠狀病毒實驗性疫苗已於西雅圖展開首項人體測試研究。



人民日報

【我國檢測試劑已經走出國門】教育部科學技術司司長雷朝滋表示,在保障我國病毒檢測需要的基礎上,我國檢測試劑已經走出國門。據不完全統計,清華大學、四川大學、廈門大學、電子科技大學、重慶醫科大學,5所高校研發14種試劑盒獲得歐盟認證,已向意大利、英國、荷蘭等11個國家供貨。


IEEE Spectrum


Serial biotech entrepreneur Jonathan Rothberg says the at-home test he's developing will detect the new coronavirus immediately, as soon as a person contracts it.



Jonathan Rothberg of 4Catalyzer says his test will give readouts on a smartphone in 30 minutes




SPECTRUM.IEEE.ORG

Biotech Pioneer Is Making a Home Test Kit for Coronavirus


Clinical microbiologists at Johns Hopkins Medicine have developed an in-house coronavirus screening test that may soon allow the health system to test as many as 1,000 people per day. As cases spread in the U.S., the test is being rolled out at five Baltimore-area hospitals.



The test is being rolled out at five Baltimore-area hospitals and could allow doctors to screen as many as 1,000 patients a day


HUB.JHU.EDU

Johns Hopkins develops in-house coronavirus screening test

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Germany's CureVac, among the vaccine developers funded by the Coalition for Epidemic Preparedness Innovations (CEPI), said it could mass-produce a coronavirus immunization from its existing facilities if its low-dose approach proves successful in trials.


REUTERS.COM

Germany's CureVac says low-dose coronavirus vaccine could allow for mass production

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據日本田邊三菱製藥公司發布消息稱,將着手開發新型冠狀病毒疫苗。其加拿大子公司已成功製作出模擬病毒的植物微粒。計畫8月之前在加拿大啟動臨床試驗,2021年內結束試驗。結束後有可能在1~2個月內生產出疫苗,如果進展順利,估計將於2022年度投入實用。

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Drugmakers are working as quickly as possible to develop a vaccine to combat the rapidly spreading coronavirus that has infected more than 100,000 people worldwide.

REUTERS.COM

As pressure for coronavirus vaccine mounts, scientists debate risks of accelerated testing

Scientific American

As they race to test an experimental coronavirus vaccine, researchers aren’t waiting to see how well it prevents infection in animals before trying it in people, breaking from the usual protocol.


In a big break from protocol, scientists are not waiting to see how well it works in animals first

SCIENTIFICAMERICAN.COM


Researchers Rush to Test Coronavirus Vaccine in People


Scientists in Israel say they are just weeks away from developing an oral vaccine which will beat coronavirus.


Officials expect the drug to be available within 90 days after it has been tested

Science and Technology Minister Ofir Akunis called it an 'exciting breakthrough'

Researchers had been working on a vaccine against a virus found in poultry

They now say if they can 'adjust the system' from the poultry coronavirus to the human one they will have 'in a few weeks a vaccine to prevent coronavirus'


製藥商Moderna交付首批新冠病毒疫苗,擬4月啟動人體試驗

製藥商Moderna已將首批快速研發的新型冠狀病毒疫苗交付給美國政府研究人員,研究人員將進行第一批人體試驗,以確定疫苗是否有助於抑制爆發於中國的這種流行病。



Four research teams at Columbia University will share a $2.1 million grant to mount an aggressive effort to identify potential antiviral drugs and antibodies for use against the new coronavirus, 2019-nCoV.



The Columbia teams will pursue four different approaches to develop drugs or antibodies that prevent the virus from replicating. Each approach will draw on prior knowledge and expertise the scientists gained while working on successful antiviral therapies against HIV and hepatitis C.



中國天津大學今天25日宣布,該校生命科學學院黃金海教授團隊已經成功研發出新型冠狀病毒“口服疫苗”;該疫苗以食品級安全釀酒酵母為載體,以新型冠狀病毒S蛋白為靶點產生抗體。此外,該團隊還聲稱,黃金海本人已經吞服4倍量口服新冠疫苗樣品,無任何副反應。此前中國已經宣布中成藥醫治新冠肺炎療效超過百分之九十。

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